Light Expanded Clay Aggregate (LECA) is one of the materials used to make lightweight concrete. In this study, two types of lightweight aggregates including LECA in both coarse and fine aggregate forms and pumice in fine aggregate form have been used to produce lightweight aggregate concrete. Coal waste is also used as partial replacement for cement. The results show that the usage of pumice as partial replacement for sand and LECA as coarse aggregate is applicable and can used for producing structural lightweight aggregate concrete. Furthermore, by using and increasing in the amount of LECA as fine aggregate, the slump of lightweight concrete in comparison to using sand, is also increased. The mixtures with LECA in both fine and coarse aggregate forms have the best results. Also, the results show that adding the coal waste improves the properties of lightweight concrete, and the optimal ratio is about 15% as partial replacement for cement by weight. In addition, gene expression programming is employed to establish empirical connections derived from experimental outcomes. In this regard, a relationship is proposed to determine the compressive strength of lightweight aggregate concrete based on the experimental data. The outcomes of gene expression programming demonstrate that the suggested formula exhibits good accuracy and efficiency in forecasting the specified parameter.